This page compiles every peer-reviewed wellness on berberine's effects on wellness health. All studies are linked directly to PubMed. Last updated: May 2026. Reviewed by Dr. Kashif Mahmood, PharmD.
Blood Sugar & Type 2 Diabetes
| Study |
Year |
Dose |
Key Finding |
Link |
| Yin et al. |
2008 |
1500mg/day |
FBG reduced 25.9%, HbA1c reduced 0.9% |
PMID:18510766 |
| Zhang et al. |
2008 |
1500mg/day |
FBG reduced 35.1%, HbA1c reduced 0.9% |
PMID:18397984 |
| Dong et al. (Meta-analysis) |
2012 |
Various |
Berberine comparable to oral hypoglycemics |
PMID:23118793 |
| Liang et al. |
2019 |
1500mg/day |
Significant HOMA-IR improvement vs placebo |
PMID:30861190 |
PCOS & Hormonal Health
| Study |
Year |
Key Finding |
Link |
| Wei et al. |
2012 |
Improved insulin resistance, reduced testosterone vs metformin in PCOS women |
PMID:22019891 |
| An et al. |
2014 |
Berberine improved menstrual regularity and lipid profiles in PCOS |
PMID:24691352 |
Cholesterol & Heart Health
| Study |
Year |
Key Finding |
Link |
| Kong et al. |
2004 |
Total cholesterol reduced 29%, LDL reduced 25% |
PMID:15531889 |
| Zhang et al. |
2008 |
Triglycerides reduced 35.9% |
PMID:18397984 |
Safety & Potency
| Study |
Year |
Key Finding |
Link |
| Funk et al. |
2018 |
Wide variability in potency among commercial berberine supplements |
PMID:29325474 |
*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any wellness.
